Tetracycline Group

Turmeric is fine with the tetracycline group of antibiotics and there are several studies indicating that curcumin significantly increases the effect of this group, as well as other antibiotics.


Synergistic antibacterial activity of Curcumin with antibiotics against Staphylococcus aureus

 Sin-Yeang Teow and Syed Atif Ali* Cluster of Oncological and Radiological Sciences, Advanced Medical and Dental Institute, Universiti Sains Malaysia (USM), Bertam, Kepala Batas, Pulau Pinang, Malaysia


The combination effect of curcumin with different antibiotics against Staphylococcus aureus.

Kamyar Mollazadeh Moghaddam, Mehrdad Iranshahi1, Mahsa Chitsazian Yazdi1, Ahmad Reza Shahverdi

Department of Pharmaceutical Biotechnology and Student Scientific Research Center, Faculty of Pharmacy, Tehran University of Medical

Sciences, Tehran, 1Department of Pharmacognosy, Faculty of Pharmacy, Mashahd University of Medical Sciences, Mashhad, Iran


In this study using disk diffusion assay we showed that the antibacterial activity of cefixime, cephotaxime, vancomycin and tetracycline can be increased by curcumin.

A clinical isolate of S. Aureus was selected as test strain.


 Tetracycline: (Achromycin V,  Actisite, Ala-Tet, Brodspec, Emtet-500, Panmycin, Robitet 500, Sumycin, Tetracap, Tetracon,

Pharmacology Mechanism of Action

Inhibits bacterial protein synthesis by binding with 30S and possibly 50S ribosomal subunits

Elimination  Half-life: 8-11 hr (normal renal function); 57-108 hr (end-stage renal disease)

Excretion: Urine (60% as unchanged drug); feces (as active form)

Turmeric Interaction: is ok with and may also minimise any effect on the liver and add to antibiotic action.


Eravacycline (Xerava,



Demeclocycline  (Declomycin,



Doxycycline (Vibramycin, Monodox, Acticlate, Adoxa, Atridox, Avidoxy, Doxy, Doxycin, Doryx, Oracea, Periostat, Adoxa, Ocudox, Doryx MPC, )

Pharmacology: Inhibits protein synthesis and, thus, bacterial growth by binding to 30S and possibly 50S ribosomal subunits of susceptible bacteria; may block dissociation of peptidyl t-RNA from ribosomes, causing RNA-dependent protein synthesis to arrest.

evaluating the safety of drugs in canine and feline pregnancy this drug is categorized as class D (Contraindicated) These drugs have been shown to cause congenital malformations or embryotoxicity.

The drug is primarily excreted into the feces via nonbiliary routes in an inactive form. The drug is thought to be partially inactivated in the intestine by chelate formation and excreted into the intestinal lumen.

Turmeric Interaction: is ok with doxycycline and may also minimise any effect on the liver, add to the anti-inflammatory effect of doxy, and add to antibiotic action.



Minocycline (Dynacin, Minocin, Minomycin, Arestin, Akamin, Aknemin, Solodyn, Sebomin, Alti-Minocycline, Apo-Minocycline, PMS-Minocycline, Minolira, Myrac, Ximino

Pharmacology: bacteriostatic in susceptible organisms, tetracyclines inhibit bacterial protein synthesis by reversibly binding to the bacterial 30S ribosomal subunits preventing aminoacyl tRNA attachment to the ribosome. Tetracyclines also alter cytoplasmic membrane permeability in susceptible organisms. At high concentrations, tetracyclines inhibit protein synthesis in mammalian cells.

Rheumatoid arthritis: Mechanism not fully understood; may play immunomodulatory, anti-inflammatory, or chondroprotective effects; thought to be a potent inhibitor of metalloproteinases, which are active in rheumatoid arthritis joint destruction.

Minocycline is extensively metabolized in the liver and excreted primarily as inactive metabolites in the feces and urine

Turmeric Interaction: is ok with minocycline and may also minimise any effect on the liver and add to the milder anti-inflammatory effect of minocycline.



Sarecycline: (Seysara